Wound Treatment Using Growth Factors

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Wound Treatment Using Growth Factors

Treatment with growth factors is an effective method to promote wound healing. Several growth factors have been used in wound treatment, including basic fibroblast growth factor (bFGF) discovered in the 1970s, platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and bone morphogenetic protein (BMP). In 2001, Kaken Pharmaceutical Co., Ltd. launched Fiblast Spray in Japan. This p...

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Growth Factors in Wound Healing

Several growth factors are potential mediators of wound healing, although their actual roles, interactions, and therapeutic use are not established. Six well-characterized human growth factors were chosen for detailed investigation by topical application to standardized skin wounds in swine: epidermal growth factor (EGF), transforming growth factors a and B (TGF-a and TGF), fibroblast growth fa...

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Growth factors in wound healing.

Enhancement of wound healing was limited to good surgical technique, maintenance of a clean wound with appropriate dressings, and debridement. The ability to heal wounds has been advanced through the recognition that healing in a moist environment is improved over that of a desiccated wound. Pharmacologic approaches to wound healing did not exist until the last few decades, when it was recogniz...

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Growth Factors in Chronic Wound Healing

©2013 Regents of the University of California and VerusMed, with permission. Unauthorized reproduction of Wound Care Update is strictly prohibited. Growth substances (cytokines and growth factors) are soluble signaling proteins affecting the process of normal wound healing. Cytokines govern the inflammatory phase that clears cellular and extracellular matrix debris. Wound repair is controlled b...

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Age and growth factors in porcine full-thickness wound healing.

It has been recognized that the rate of cutaneous wound healing declines with age, yet the molecular processes that affect this decline remain poorly understood. The purpose of this study was to compare reepithelialization and contraction rates, and growth factor profiles in full-thickness wounds in swine of various ages. Multiple full-thickness excisional wounds were created on the dorsum of 2...

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ژورنال

عنوان ژورنال: Modern Plastic Surgery

سال: 2013

ISSN: 2164-5213,2164-5280

DOI: 10.4236/mps.2013.33022